A - Human Necessities – 61 – K

Patent

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Details

A61K 39/385 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2418899

The invention concerns vaccines comprising as active principle an immunogen which is a cytokinetic factor or a cell regulating factor particularly transcriptional or another type of factor with immunosuppressive/apoptotic/angiogenic properties abnormally released in the extracellular (stromal) environment by cancer or stromal cells of malignant tumours, and a pharmaceutically acceptable carrier for inducing a systemic or mucosal immune response with secretory formation of class IgC or IgA neutralising antibodies directed against the native factor, or which is derived from such a factor and the use of said immunogen to obtain a medicine for use as anticancer drug.

Vaccines renfermant à titre de principe actif un immunogène qui est un facteur cytokinique ou un facteur de régulation cellulaire particulièrement transcriptionnel ou un autre type de facteur à propriétés immunosuppressives/apoptotiques/angiogéniques anormalement relâché dans le milieu extracellulaire (stromal) par les cellules cancéreuses ou stromales de tumeurs malignes, ainsi qu'un excipient pharmaceutiquement acceptable permettant l'induction d'une réaction immuniataire systèmique ou mucosale avec formation d'anticorps neutralisants de classe IgG ou IgA sécrétoire dirigée contre le facteur natif, ou qui dérive d'un tel facteur et utilisation d'un tel immunogène pour l'obtention d'un médicament destiné à une utilisation en tant qu'anticancéreux.

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