1,3-dioxolane derivatives as cholesterol-lowering agents

C - Chemistry – Metallurgy – 07 – D

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C07D 405/06 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2058068

27200-FF ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) wherein n is 2 or 3; p is 0, 1 or 2; q is 0, 1 or 2; X is oxygen or S(O)t where t is 0, 1 or 2; each R1 is independently halo, lower alkyl, lower alkoxy, or trifluoromethyl; each R2 is independently halo or lower alkyl; R3 is nitro or -N(R5)R6 where R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylsulfonyl or -C(Y)R7 where Y is oxygen or sulfur and R7 is hydrogen, lower alkyl, lower alkoxy or -N(R3)R9 where R8 is hydrogen or lower alkyl and R9 is hydrogen, lower alkyl or lower alkoxycarbonyl; or 9459M/9460M/9461M 27200-FF R5 and R6 together with N is pyrrolidino, piperidino, morpholino, thiomorpholino or piperazino, wherein the piperazino is optionally substituted at the 4-position by -C(O)R10 where R10 is hydrogen, lower alkyl, lower alkoxy or amino; and R4 is hydrogen or lower alkyl, as single stereoisomers or as mixtures thereof; and their pharmaceutically acceptable salts, are useful in treating disease-states characterized by hypercholesterolemia. 9459M/9460M/9461M 27200-FF

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