A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/44 (2006.01) A61K 31/59 (2006.01) A61K 47/00 (2006.01) A61K 47/06 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01)
Patent
CA 2148109
A 1.alpha.,24-(OH)2-V.D3 cream composition comprising (a) a therapeutically effective amount of 1.alpha.,24-(OH)2-V.D3, (b) an oil phase component including (i) a solid oil component composed of 5 to 20 parts by weight of white petrolatum and 5 to 15 parts by weight of higher alcohols and (ii) a liquid oil component comprising of 3 to parts by weight of squalane, (c) an aqueous phase component, and (d) 2.5 to 7.5 parts by weight at least two surfactants, wherein the 1.alpha.,24-(OH)2-V.D3 cream composition has a weight ratio of the solid oil component to the liquid oil component (i.e., solid oil component/liquid oil component) of at least approximately 2, the higher alcohols are composed of stearyl alcohol and cetyl alcohol, the weight ratio of the stearyl alcohol to the higher alcohols (i.e., stearyl alcohol/higher alcohols) is approximately 0.65 to approximately 0.9, at least 50% by weight of the surfactants is at least one surfactant having an HLB value of approximately 5 or less, and the HLB value of the surfactants as a whole is approximately 8 to approximately 18.
Une crème à base de 1 alpha ,24-(OH)2-vitamine D3 comprend: a) une quantité, disponible sur le plan thérapeutique, de 1 alpha ,24-(OH)2-vitamine D3; b) un composant en phrase huileuse qui comprend: 1) un composant en phase huileuse solide qui comporte (i) 5 à 20 parties en poids de vaseline blanche et 5 à 15 parties en poids d'un alcool supérieur et 2) un composant huileux liquide qui comporte 3 à 10 parties en poids de squalane; c) un composant en phase aqueuse; et d) 2,5 à 7,5 parties en poids de deux tensioactifs ou plus. Le rapport du composant huileux solide au composant huileux liquide est d'environ 2 ou plus et l'alcool supérieur est un mélange d'alcool octadécylique et d'alcool hexadécylique, le rapport pondéral du premier atteignant environ 0,65 à 0,9 de celui du mélange. Les tensioactifs comprennent au moins 50 % en poids d'un tensioactif qui présente une valeur HLB d'environ 5 au moins, et la valeur HLB de l'ensemble de ces tensioactifs varie d'environ 8 à environ 18.
Makino Yuji
Matugi Hideo
Suzuki Yoshiki
Mcfadden Fincham
Teijin Limited
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