(1-aza-bicyclo[3.3.1]...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/08 (2006.01) A61K 31/439 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2632893

The present invention relates to compounds of formula (I) wherein n represents 0, 1, 2, 3, 4 or 5, R represents independent from each other hydroxyl, cyano, nitro, halogen, alkyl, alkoxy alkylcarbonyl, alkoxycarbonyl, alkylamine, dialkylamine, alkylcarbonylamine, alkylcarbamate Y represents one of the following groups: (Ia) in free base or acid addition salt form, to processes for their production, to pharmaceutical compositions comprising them and their use in the manufacture of a medicament for the treatment and/or delay of progression of psychotic and neurodegenerative disorders.

La présente invention concerne des composés de formule (I) où n représente 0, 1, 2, 3, 4 ou 5, R représente de façon indépendante un groupement hydroxy, cyano, nitro, halogéno, alkyle, alcoxy, alkylcarbonyle, alcoxycarbonyle, alkylamine, dialkylamine, alkylcarbonylamine, alkylcarbamate, Y représente l'un des groupements suivants : (Ia) sous forme de base libre ou de sels d'addition acide, ainsi que des procédés de production desdits composés, des préparations pharmaceutiques les incluant et leur emploi dans la fabrication d'un médicament pour le traitement et/ou le ralentissement de la progression de troubles psychotiques et neurodégénératifs.

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