11-substituted steroids of the estrane series

C - Chemistry – Metallurgy – 07 – J

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C07J 1/00 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) C07J 11/00 (2006.01) C07J 13/00 (2006.01) C07J 17/00 (2006.01) C07J 21/00 (2006.01) C07J 33/00 (2006.01) C07J 43/00 (2006.01)

Patent

CA 1056370

Title: Novel 11-substituted steroids of the estrane series. Abstract of the Disclosure The present invention relates to novel 11-substituted steroids of the estrane series having the general formula Image , in which R1 = a free, esterified or etherified hydroxyl group or halogen; R2 = an alkyl group with 1-4 C-atoms; R3 = 0 or (.alpha.Y) (.beta.Z), in which Y = H or a saturated or un- saturated alkyl group with 1-4 C-atoms and Z = a free, esterified or etherified hydroxyl group; R4 = H or a free or esterified hydroxyl group; and ring A including carbon atom 6 is Image or Image , in which R5 = H or a free, esterified or etherified hydroxyl group, R6 = H2, O or H(R7), R7 = a free, esterified or etherified hydroxyl group and a double bond is present starting from carbon atom 5, and to processes for their preparation. The compounds according to the present invention are of value for their contraceptive, estrogenic, progestatio- nal, ovulation-inhibiting, gonad-inhibiting and anabolic properties.

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