2-amino-4-morpholino-6-propyl-1,3,5-triazines

Details 2-amino-4-morpholino-6-propyl-1,3,5-triazines 2-amino-4-morpholino-6-propyl-1,3,5-triazines

C - Chemistry, Metallurgy

07

D

167/215, 260/245

C07D 413/04 (2006.01) A61K 31/535 (2006.01) C07D 251/18 (2006.01) C07D 413/14 (2006.01)

Patent

CA 1317944

A B S T R A C T. New 2-amino-4-morpholino-6-propyl-1,3,5-triazines having the formula (I) Image wherein R1 is hydrogen, alkyl, aralkyl or acetyl, R2 is hydroxyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, aryl- hydroxyalkyl, (hydroxy-cycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR3 or C0NR4R5, or NR1R2 = (hydroxyalkyl)alkyleneimino, R3 = alkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, R4 = R5 = hydrogen or alkyl, alkyl, alkoxy and alkanoyloxy having 1 to 4 carbon atoms, cycloalkyl and alkyleneimino having 4 to 6 carbon atoms. Moreover, when R1 is acetyl, is acetoxyalkyl. Processes for the preparation thereof and pharmaceutical compositions containing the same are also given. In particular, these compounds are useful for the treatment of cognitive and behavioral disorders associated with aging and dementia syndromes, e.g. those associated with Alzheimer's disease.

607834

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