2-hydroxy-3-¬1-(1h-imidazol-4-yl)alkyl|-benzenecarboximidamides

Details 2-hydroxy-3-¬1-(1h-imidazol-4-yl)alkyl|-benzenecarboximidamides 2-hydroxy-3-¬1-(1h-imidazol-4-yl)alkyl|-benzenecarboximidamides

C - Chemistry, Metallurgy

07

D

C07D 233/64 (2006.01) A61K 31/415 (2006.01) C07D 233/54 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2124289

ABSTRACT New 2-hydroxy-3-(1-(1H-imidazol-4-yl)alkyl]- benzenecarboximidamides as well as their salts, having the formula Image (I) wherein R1 is hydrogen or an alkyl radical having 1 to 4 carbon atoms, R2 is hydrogen, a hydroxyl group, an amino group or an alkyl radical having 1 to 4 carbon atoms, R3 is hydrogen, or R2 and R3 together are -CH2-CH2-; processes for the preparation thereof, and ophthalmic compositions comprising the same are also described. These compounds are capable of lowering intraocular pressure and can be used in the prevention and treatment of glaucoma.

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