4'-demethylepipodophyllotoxin glycosides

Details 4'-demethylepipodophyllotoxin glycosides 4'-demethylepipodophyllotoxin glycosides

C - Chemistry, Metallurgy

07

H

260/233.5

C07H 17/04 (2006.01)

Patent

CA 2039874

The present invention relates to antitumor 4'-demethylepipodophyllotoxin glycosides having the formula Image wherein R is a pentose selected from the group consisting of .beta.-D-ribopyranosyl, peracyl .beta.-D-ribopyranosyl, .beta.-D-xylopyranosyl, peracyl .beta.-D-xylopyranosyl, .alpha.-D-xylopyranosyl, peracyl .alpha.-D-xylopyranosyl, .alpha.-D-arabinopyranosyl, 3,4-O-(C1-4)alkylidene-D-ribopyranosyl, 2-O-acyl-3,4-O-(C1-4)alkylidene-D-ribopyranosyl, and .beta.-D-ribofuranosyl; P is hydrogen, or -PO3H2 or a pharmaceutically acceptable salt thereof.

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