4-substituted alkyl carbapenem antibiotics

Details 4-substituted alkyl carbapenem antibiotics 4-substituted alkyl carbapenem antibiotics

C - Chemistry, Metallurgy

07

D

260/299, 530/5.0

C07D 487/04 (2006.01) C07D 205/08 (2006.01) C07D 401/12 (2006.01) C07D 477/20 (2006.01) C07D 521/00 (2006.01) C07F 7/10 (2006.01) C07K 2/00 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2031487

Compounds of the formula Image wherein R1 is hydrogen, C1-2 alkyl, -CH2OH, -CH2NH2, Image , Image or Image ; A is an unsubstituted or hydroxy-substituted straight or branched C1-10 alkylene group or a straight or branched C1-10 alkylene group having an intervening heteroatom selected from oxygen, sulfur and nitrogen; R2 is hydroxy, halogen, C1-4 alkoxy, nitrile, azido, a quaternary ammonio group, -NR5R6, Image , azetidinyl, or a 5- or 6-membered heterocyclic group selected from heteroaromatic and heteroalicyclic joined through a carbon atom thereof; B is a straight or branched C1-6 alkylene group or a direct bond when R3 is joined to the sulfur atom through a carbon atom thereof; R3 is a residue of an organic group; R4 is hydrogen, a removable carboxy-protecting group or a physiologically hydrolyzable ester group; R5 and R6 each are independently hydrogen, C1-6 alkyl, C1-4 alkoxy, hydroxyethyl, azidoethyl, aminoethyl, and when R5 is hydrogen or C1-4 alkyl, R6 is hydroxy, C1-4 alkoxy; amino, C1-4 alkylamino, di(C1-4)- alkylamino, substituted C1-4 alkyl wherein said alkyl substituent is selected from hydroxy, azido, amino, guanidino, nitrile, carboxy, formimidoyl and phenyl, or an acyl residue of an amino acid or peptide; or R5 and R6, taken together with the nitrogen atom to which they are attached, is an unsubstituted or substituted heterocyclic ring having 1 to 2 ring members and having up to four heteroatoms in each ring independently selected from oxygen, nitrogen and sulfur, wherein said substituent is selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, hydroxy, halogen, amino, nitrile, carboxy, carbamido, carbamoyl, C1-4 alkylamino and amino (C1-4)alkyl; W is a direct bond, oxygen, sulfur or NR10; Y is oxygen or NR10; Z is hydrogen, hydroxy, C1-4 alkyl, C1-4alkoxy, -NR7R8, amino(C1-4)alkyl, azido(C1-4)alkyl or hydroxy (C1-4)alkyl; R7 and R8 each are independently hydrogen, C1-4 alkyl or alkanoyl; and R10 is hydrogen, C1-4 alkyl, C1-4 alkylamino or di(C1-4)alkylamino; or a non-toxic pharmaceutically acceptable salt thereof, are novel antimicrobial agents which are useful in the treatment of infectious disease in humans and other animals. Novel intermediates and processes for their preparation are also disclosed.

Affiliated with

Also associated with

Rating

4-substituted alkyl carbapenem antibiotics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-substituted alkyl carbapenem antibiotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-substituted alkyl carbapenem antibiotics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1456529