Alpha-alkyl polyolefinic carboxylic acids and derivatives...

Details Alpha-alkyl polyolefinic carboxylic acids and derivatives... Alpha-alkyl polyolefinic carboxylic acids and derivatives...

C - Chemistry, Metallurgy

07

C

167/246, 260/518

C07C 403/20 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/20 (2006.01) A61K 31/215 (2006.01) A61K 31/23 (2006.01)

Patent

CA 1278308

ABSTRACT OF THE DISCLOSURE Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula Image in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is an alkyl group of from 1 to 5 carbon atoms; R3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH2,NHR2 or NR2R2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis.

431328

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