C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/10 (2006.01) A61K 31/41 (2006.01) C07C 45/30 (2006.01) C07C 235/38 (2006.01) C07C 271/00 (2006.01) C07D 213/73 (2006.01) C07D 213/74 (2006.01) C07D 231/12 (2006.01) C07D 231/20 (2006.01) C07D 231/38 (2006.01) C07D 233/20 (2006.01) C07D 233/54 (2006.01) C07D 233/72 (2006.01) C07D 233/88 (2006.01) C07D 239/54 (2006.01) C07D 249/02 (2006.01) C07D 249/04 (2006.01) C07D 249/14 (2006.01) C07D 263/30 (2006.01) C07D 271/02 (2006.01) C07D 277/20 (2006.01) C07D 285/04 (2006.01)
Patent
CA 2193725
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess similar or improved PDE IV inhibition as compared to rolipram, with improved selectivity with regard to, e.g., PDE III inhibition. Preferred compounds are 3-(3-cyclopentyloxy-4-methoxy-benzylamino)-4- hydroxymethyl pyrazole and 3-(3-cyclopentyloxy-4-methoxybenzylamino)-4- methoxymethylpyrazole.
Nouveaux composés qui sont des inhibiteurs efficaces de la PDE IV. Lesdits composés présentent un pouvoir d'inhibition similaire ou amélioré de la PDE IV par rapport à celui du rolipram, ainsi qu'une sélectivité améliorée concernant, par ex., l'inhibition de la PDE III. Des composés préférés sont le 3-(3-cyclopentyloxy-4-méthoxybenzylamino)-4-hydroxyméthyle pyrazole et le 3-(3-cyclopentyloxy-4-méthoxybenzylamino)-4-méthoxyméthyle pyrazole.
Cavalla David
Chasin Mark
Dolby Lloyd
Frith Richard W.
Borden Ladner Gervais Llp
Euro-Celtique S.a.
Euroceltique S.a.
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