A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5377 (2006.01) A61K 31/395 (2006.01) A61P 35/00 (2006.01) C07D 225/06 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2456175
The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
L'invention se rapporte à des analogues de l'ansamycine benzoquinone, servant à traiter le cancer et d'autres maladies ou états caractérisés par une prolifération ou une hyperprolifération cellulaires indésirables. Des thérapies consistant à administrer lesdits analogues de l'ansamycine benzoquinone, éventuellement en combinaison avec un inhibiteur d'une protéine cliente HSP90, sont efficaces pour le traitement du cancer et d'états pathologiques non cancéreux.
Feng Li
Hutchinson C. Richard
Johnson Robert
Myles David C.
Santi Daniel
Fetherstonhaugh & Co.
Kosan Biosciences Inc.
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