Combined electrophoresis-electrospray interface and method

Details Combined electrophoresis-electrospray interface and method Combined electrophoresis-electrospray interface and method

G - Physics

01

N

204/171, 358/9,

G01N 27/447 (2006.01) G01N 27/62 (2006.01) H01J 49/04 (2006.01) H01J 49/16 (2006.01)

Patent

CA 1340133

A system and method for analyzing molecular constituents of a composition sample includes: forming a solution of the sample, separating the solution by capillary electrophoresis into an eluent of constituents longitudinally separated according to their relative electrophoretic mobilities, electrospraying the eluent to form a charged spray in which the molecular constituents have a temporal distribution; and detecting or collecting the separated constituents in accordance with the temporal distribution in the spray. A first high-voltage (e.g., 5-100 KVDC) is applied to the solution. The spray is charged by applying a second high voltage (e.g., +/- 2-8 KVDC) between the eluent at the capillary exit and a cathode spaced in front of the exit. A complete electrical circuit is formed by a conductor which directly contacts the eluent at the capillary exit, or by conduction through a sheath electrode discharged in an annular sheath flow about the capillary exit.

563449

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