Controlled release formulations coated with aqueous...

A - Human Necessities – 61 – K

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A61K 9/32 (2006.01) A01N 25/26 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 31/485 (2006.01) C05G 3/00 (2006.01) A61K 7/00 (1995.01) A61K 7/40 (1995.01)

Patent

CA 2128591

A stable solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic acrylic polymer includes a substrate including an active agent selected from the group consisting of a systemically active therapeutic agent, a locally active therapeutic agent, a disinfecting and sanitizing agent, a cleansing agent, a fragrance agent and a fertilizing agent, overcoated with an aqueous dispersion of the plasticized water-insoluble acrylic polymer. The formulation provides a stable dissolution of the active agent which is unchanged after exposure to accelerated storage conditions.

Une formulation solide, stable, à libération prolongée, recouverte d'un enrobage constitué d'une dispersion aqueuse d'un polymère acrylique hydrophobe comprend un substrat, incluant un agent actif choisi dans le groupe constitué d'un agent thérapeutique actif sur le plan systémique, un agent actif sur le plan local, un désinfectant, un nettoyant, un parfum et un fertilisant, recouvert d'une dispersion aqueuse du polymère acrylique insoluble dans l'eau plastifié. La formulation permet à l'agent actif de se dissoudre de façon stable même après une exposition à des conditions d'entreposage accélérées.

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