Injection composition containing an antibacterial...

A - Human Necessities – 61 – K

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A61K 47/00 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/70 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01)

Patent

CA 1267091

A B S T R A C T The invention relates to a process for the preparation of colour and pH stabilized aqueous parenteral pharmaceutical compositions comprising an antibacterial aminoglycoside comprising a pyranose ring being unsaturated between positions 4' and 5' and substituted with an aminoalkyl group at position 5', preferably sisomicine, netylmicine or 5-epi-sisomicine or the parenterally acceptable salts thereof. According to the process of the invention the active ingredient is dissolved in water, the pH of the solution is adjusted to 7,3 - 7,4, an antioxidant is added to the solution, nitrogen gas is bubbled through the solution after sterile filtration and the solution thus obtained is filled into ampoules.

503435

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