Intermediate of making pteridine compounds

Details Intermediate of making pteridine compounds Intermediate of making pteridine compounds

C - Chemistry, Metallurgy

07

D

260/242.1

C07D 475/08 (2006.01)

Patent

CA 1081224

ABSTRACT OF THE DISCLOSURE The present invention relates to 6(bromo ethyl)-2,4- diamino pteridine hydrobromide which is useful as an inter- mediate in the preparation of pteridine compounds such as metho- trexate. 2,4-diamino-6-pteridine-methanol?HBr is reacted with triphenylphosphine dibromide or phosphorus tribromide to form the 6-(bromomethyl)-2,4-diamino-pteridine hydrobromide. The bromine atom in the molecule may then be replaced with the functional group, N-[4-(methylamino)-benzoyl]-L-glutamic acid in the case of methotrexate and N-(4-aminobenzoyl)-L-glutamic acid in the case of aminopterin.

320716

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