Methods employing combinatorial artificial receptors

G - Physics – 01 – N

Patent

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G01N 33/543 (2006.01)

Patent

CA 2537306

The present invention relates to methods employing receptors, such as combinatorial artificial receptor arrays. The present receptors include heterogeneous and immobilized combinations of building block molecules. In certain embodiments, combinations of 2, 3, 4, or 5 distinct building block molecules immobilized near one another on a support provide molecular structures that can be employed in the present methods. The present methods can develop artificial receptors that can then be employed to detect the receptor~s ligand. The present methods can find compounds that disrupt one or more binding interactions.

L'invention concerne des procédés utilisant des récepteurs artificiels tels que des réseaux de récepteurs artificiels combinés. Ces récepteurs comprennent des combinaisons hétérogènes et immobilisées de molécules éléments structuraux. Dans certaines formes de réalisation, des combinaisons de 2, 3, 4, ou 5 molécules éléments structuraux distinctes, qui sont immobilisées sur un support et proches les unes des autres, forment des structures moléculaires pouvant être utilisées dans les procédés de l'invention. Ces procédés permettent de mettre au point des récepteurs artificiels pouvant servir à détecter le ligand du récepteur, et de trouver des composés pouvant interrompre une ou plusieurs interactions de liaison.

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