(r)-.alpha.-ethyl-2-oxo-l-pyrrolidineacetamide

C - Chemistry – Metallurgy – 07 – D

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C07D 207/27 (2006.01)

Patent

CA 1237138

ABSTRACT OF THE DISCLOSURE: The invention relates to (R)-alpha-ethyl-2-oxo-1- pyrrolidineacetamide of the formula: Image and to its preparation either by reacting (R)-alpha-ethyl-2- oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or by cyclizing an (R)-2- amino-butanamide of the formula X-CH2CH2-Y-NHCH(C2H5)CONH2 wherein Y is a -CH2- radical when X represents a ZOOC- radical and Y is a -CO- radical when X represents a HalCH2- radical, Z being a C1-C4 alkyl radical and Hal a halogen atom. This dextrorotatory enantiomer has been found to have significantly higher mnemic activity and lower toxicity than the corresponding racemate.

481511

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