Single-stage process for preparing mixed-substituted...

Details Single-stage process for preparing mixed-substituted... Single-stage process for preparing mixed-substituted...

C - Chemistry, Metallurgy

07

F

260/460.6

C07F 9/10 (2006.01)

Patent

CA 1300637

Abstract Single-stage process for preparing mixed-sub- stituted enantiomerically pure 1,2-diacyl-sn-glycero-3- phosphocholines of the general formula I Image (I) in which R1 and R2 are different and independently of each other denote a substituted or unsubstituted C1 to C24-alkyl or C3 to C24-alkenyl radical, by reacting 1-0-triphenyl- methyl-2-acyl-sn-glycero-3-phosphocholine of the general formula II of the sheet of formulae, in which T denotes a substituted or unsubstituted triphenylmethyl group and R2 is as defined above, with a reactive carboxylic acid deri- vative of the general formula III of the sheet of formulae, in which R1 is as defined above and X denotes a carboxylic acid radical, a carbonic acid radical, a sulfonic acid ra- dical or the radical of a fused or unfused five-membered heterocycle having at least two N atoms in the ring, in the presence of a protonic acid, of a Lewis acid or of adducts thereof with electron donors, and isolating the resulting compounds of the general formula I from the reaction mix- ture.

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