Stabilized erythrocytes by glyoxal and formaldehyde

Details Stabilized erythrocytes by glyoxal and formaldehyde Stabilized erythrocytes by glyoxal and formaldehyde

A - Human Necessities

61

K

167/114, 167/45

A61K 35/18 (2006.01) A61K 39/00 (2006.01) G01N 33/556 (2006.01)

Patent

CA 1090700

ABSTRACT OF THE INVENTION A double aldehyde treatment process of erythrocytes is disclosed. Erythrocytes from various sources can be treated in a two-step process to render them stable and subsequently useful in antigen antibody detection systems. Glyoxal is used as a first treating medium followed by a second treatment step using formaldehyde or glyoxal as amounts ranging from 0.1 to 0.4 gm. per 0.8 ml. of Packed Cell Volume of erythrocytes, followed by the second treatment step in which at least 0.1 gm. of formaldehyde or glyoxal and preferably 0.1 to 0.6 gm. per 0.8 ml. Packed Cell Volume of treated erythrocytes is used. The reaction medium is preferably aqueous hypertonic and most preferably a sodium citrate medium. The treated cells can be used in detection of hepatitis associated antigen in a reverse passive hemagglutination test.

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