C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/58
C07J 1/00 (2006.01) C07J 31/00 (2006.01) C07J 53/00 (2006.01)
Patent
CA 1114807
ABSRRACT Novel steroids, which can be used as antiinflammatory agents, have the formula Image or the 1,2-dehydro derivative thereof, wherein X is -S-, -?- or -?-; R1 is alkyl, aryl or acyloxyalkyl; R2 and R3 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, alkyl-?-, alkyl-?-O-, hydroxy, halogen, phenyl or cyano, wtih the proviso that when R2 and R3 are different, one of R2 and R3 is hydrogen; R4 is carbonyl, .beta.-hydroxymethylene or .beta.-acyloxy- methylene; R5 is hydrogen or halogen; and R6 is hydrogen or fluorine; wherein the term "aryl" refers to phenyl or phenyl substituted with one or two alkyl, alkoxy or halogen sub- stituents; the term "acyloxy" refers to a grow having the formula Y-?-O- wherein Y is alkyl or aryl; and the terms "alkyl" and "alkoxy" refer to groups having 1 to 10 carbons atoms.
301586
Osler Hoskin & Harcourt Llp
Squibb (e.r.) & Sons Inc.
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