Process for the preparation of derivatives of 1,3...

Details Process for the preparation of derivatives of 1,3... Process for the preparation of derivatives of 1,3...

C - Chemistry, Metallurgy

07

D

260/279

C07D 401/14 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1131230

PRECIS DE LA DIVULGATION: L'invention concerne un procédé de préparation de nouveaux dérivés de la 1,3-dihydro 3-[1-[2-(2,3-dihydro 1,4- benzodioxin-2-yl) 2-hydroxy éthyl] pipéridin-4-yl] 2H-indol 2-one répondant à la formule générale I : Image (I) dans laquelle R1 est un hydrogène ou un alcoxy de 1 à 5 atomes de carbone, R2 un hydrogène ou un alcoyle de 1 à 5 atomes de carbone, sous formes racémiques ou optique- ment actives, ainsi que leurs sels d'addition avec les acides minéraux ou organiques. Les dérivés de l'invention manifestent une importante activité antihypertensive.

323918

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