Immunochemical conjugates: method and composition

Details Immunochemical conjugates: method and composition Immunochemical conjugates: method and composition

A - Human Necessities

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A61K 39/00 (2006.01) A61K 39/36 (2006.01) A61K 47/48 (2006.01) C07K 1/10 (2006.01) C07K 14/62 (2006.01) A61K 38/11 (2006.01)

Patent

CA 1138438

Abstract of the Disclosure Techniques for preparing stable conjugates of protein-?-GL which can then be isolated in pure form are disclosed, using hen egg ovalbumin (OVA) as a prototype protein, and conjugation and purification methods are described which involve 1) application of a coupling method employing m-maleimidobenzoyl-N- hydroxysuccinimide ester (MBS) as the coupling reagent, and 2) introduction of biotin moieties into ?-GL molecules to allow application of avidin- biotin system for affinity chromatographic purification of conjugates. These methods are applicable to the preparation of ?-GL conjugates of insulin and Ragweed Antigen E and are of general applicability.

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