Substituted imidazoles, their preparation and use

Details Substituted imidazoles, their preparation and use Substituted imidazoles, their preparation and use

C - Chemistry, Metallurgy

07

D

260/242, 260/277

C07D 233/64 (2006.01) C07D 403/00 (2006.01)

Patent

CA 1075689

ABSTRACT OF THE DISCLOSURE The invention relates to novel imidazoles of the formula: Image wherelr. R and R1 are independently selected from hydrogen, C1-C10 alkyl, substituted C1-C10 alkyl having 1-3 substituents, aryl, substituted aryl having 1-5 substituents, heterocyclic group having 5-6 ring atoms, halogen, cyano, carboxy and carboxy derivatives, and Image wherein Ra is H or C1-C6 alkyl, R2 is selected from hydrogen, C1-C10 alkyl, hydroxy-C1-C10- alkyl and C3-C6 alkeny1, R3 is aryl having 6 ring atoms of which 0-2 are non-carbon, substituted aryl having 1-4 substit- uents, fused ring aryl havlng 9-10 ring atoms of which 0-2 are non-carbon and substituted fused ring aryl having 1-4 substit- uents, R4 is selected from hydroxy and Image wherein Rb is C1-C6 alkyl, and, R5 and R6 when separate are independently selected from hydrogcn, C1-C6 alkyl and substituted C1-C6 alkyl and, when joined form a 5-6 membered -N-alicyclic ring. These compounds possess antihypertensive and .beta.-adrenergic blocking activity.

257658

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