Process for preparing substituted aminoquinazoline...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/04 (2006.01) C07D 239/95 (2006.01) C07D 295/00 (2006.01)

Patent

CA 1068698

ABSTRACT OF THE DISCLOSURE 2-(4-Substituted piperazin-1-yl)-4-amino-6,7-dimethoxy- quinazolines and 2-(4-substituted piperazin-1-yl)-4-amino- 6,7,8-trimethoxyquinazolines are produced by reacting certain 2-chloro (or bromo)-4-(substituted amino)quinazolines with the appropriate 1-substituted piperazine to obtain the de- sired compounds directly or a 2-(4-substituted piperazin-1-yl)- 4-(substituted amino)quinazoline; in the latter case the substitutent on the 4-amino group of the quinazoline is selectively removed to provide the desired compounds. The products are known hypotensive agents.

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