C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/653.2, 260/5
C07C 25/24 (2006.01) C07C 121/70 (1980.01) C07C 143/68 (1980.01)
Patent
CA 1040647
ABSTRACT OF THE DISCLOSURE Novel intermediates and their process of preparation are provided which are useful in the preparation of substituted 3-amino-prop-1-enes which have a trypanocidal effect and can be used in the treatment of infections caused by Trypanoaoma cruzi, for example, Chagas' disease, the intermediates have the formula (V) Image (V) wherein with certain provisions R1 and R2 are the same or different and are selected from halo-substituted or unsubstituted bi- phenylyl, or halo-substituted or unsubstituted phenyl group, and Q and G taken together represent a single bond, or Q is a hydroxyl group and G is a hydrogen atom; and M is selected from a nitrile group; a group of formula CONR3R4; a group of formula CH2A where A represents a nitrile group, a leaving group, for example, bromo or tosyloxy, or a group NR3COR9 where R9 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms and where R3 and R4 are the same or different and can each represent a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms.
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