Process for the manufacture of novel antigens

Details Process for the manufacture of novel antigens Process for the manufacture of novel antigens

A - Human Necessities

61

K

167/129, 530/15.

A61K 39/00 (2006.01) A61K 39/385 (2006.01) C07H 9/04 (2006.01) C07H 23/00 (2006.01) C07K 9/00 (2006.01)

Patent

CA 1138436

A B S T R A C T New antigen derivatives are disclosed which comprise an antigen and at least one muramyl-peptide covalently bonded thereto, if appropriate by a bridge member. The derivatives may be represented by the formula: A - [Z0-1 - MP ]n in which A is the radical of an antigen, Z is a bridge member, MP is a muramyl-peptide radical and n is a positive integer. The novel derivatives provide a marked potentiation of the immuno-response to the antigen, in particular a cell-mediated immunity under clinically acceptable conditions of administration.

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