Benzofurancarboxylic acid ester derivatives

Details Benzofurancarboxylic acid ester derivatives Benzofurancarboxylic acid ester derivatives

C - Chemistry, Metallurgy

07

D

260/328.6, 260/3

C07D 409/04 (2006.01) C07C 45/00 (2006.01) C07D 307/85 (2006.01)

Patent

CA 1144173

ABSTRACT This invention relates to benzofuran carboxylic acid ester derivatives. There are provided benzofurancarboxylic acid ester derivatives of formula Image (I) wherein R is a substituent at the 5-position on the benzofuran ring system and is a thienyl group, or a phenyl, phenoxy, benzyl or benzoyl group substituted by a group selected from alkoxy of 1 to 6 carbon atoms, hydroxy, acetyl, acetyloxy, 1-hydroxyethyl, acetamido and amino, or is a substituent at the 4-position of the benzofuran ring system and is a phenoxy group optionally substitu- ted by a group selected from alkyl and alkoxy of 1 to 6 carbon atoms, hydroxy, acetyloxy, 1-hydroxyethyl, acetamido, amino, fluoro, chloro, bromo and nitro; R1 and R2 represent hydrogen atoms or R1 and R2 together represent a single chemical bond; and R3 represents and alkoxy group of from 1 to 4 carbon atoms or a 2- propenyloxy group. Compounds of formula I have exhibited lipogenesis inhib- iting activity and thus find use in animal husbandry to provide a leaner carcass after slaughter.

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