Blood preservation by polymer releasing phosphate

Details Blood preservation by polymer releasing phosphate Blood preservation by polymer releasing phosphate

A - Human Necessities

61

K

167/322

A61K 35/14 (2006.01) A01N 1/02 (2006.01) A61K 35/16 (2006.01) A61K 35/18 (2006.01)

Patent

CA 1108058

ABSTRACT OF THE DISCLOSURE The useful shelf life of living erythrocytes suitable for trans- fusion is extended by maintaining adequate ATP and 2,3 DPG levels using a water insoluble polymer containing releaseable phosphate ions as a source of inorganic phosphate ions during the storage period for supplying physiologically acceptable, continuous sustained release of metabolizable phosphate to such erythrocyte. This maintains the ATP and the 2,3 levels at least equal to those of freshly drawn blood for a storage period equivalent to 28 days of storage at 4°C.

304927

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