Stable composition of s-adenosyle-l-methionine

Details Stable composition of s-adenosyle-l-methionine Stable composition of s-adenosyle-l-methionine

A - Human Necessities

61

K

167/202

A61K 31/70 (2006.01) C07H 19/16 (2006.01)

Patent

CA 1158556

ABSTRACT OF THE DISCLOSURE A stable composition of S-adenosyl-L-methionine is disclosed which includes a salt of S-adenosyl-L-methionine and a pharmaceu- tically acceptable, water-soluble salt of a bivalent or trivalent metal. The salt of S-adenosyl-L-methionine is, for example, a salt of S-adenosyl-L-methionine with hydrochloric acid, sulfuric acid, p-toluenesulfonic acid, phosphoric acid, formic acid, acetic acid, citric acid, tartaric acid, or maleic acid ; or a double salt of S-adenosyl-L-methionine with the foregoing acids. The salt of a bivalent or trivalent metal is, for example, calcium chloride, ferric chloride, magnesium chloride, or magnesium sulfate. A process for preparing the composition is also disclosed. The composition is suitable for preparing pharmaceutical preparations of S-adenosyl-L-methionine.

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