Substituted phenylguanidines and processes for their...

Details Substituted phenylguanidines and processes for their... Substituted phenylguanidines and processes for their...

A - Human Necessities

61

K

260/468.8

A61K 31/155 (2006.01)

Patent

CA 1071649

SUBSTITUTED PHENYLGUANIDINES AND PROCESSES FOR THEIR PREPARATION AND USE Abstract N-[2-(Substituted amido)phenyl]-N',N"-bis- carbonylguanidines of the formula: Image wherein X is oxygen, sulfur, sulfinyl or sulfonyl; one of R and R1 is -COR4 and the other is Image in which R4 is hydrogen or an unsubstituted or substituted alkyl, cycloalkyl, alkoxy, aryl or amino group; R5 is an unsubstituted or substituted alkyl, alkenyl or alkynyl group; and R6 is hydrogen or an unsubstituted or substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, alkoxy, alkenyloxy or alkynyloxy group; and each of R2 and R3 independent of the other is hydrogen, halogeno, cyano, or an unsubstituted or substituted alkyl, alkoxy, alkylthio, halogenoalkyl, amino or carbalkoxy group, are prepared therough the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis- carbomethoxyguanidine is a typical example, are anthelmintic agents.

226458

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