Process for the preparation of 2-amino-benzylamines

Details Process for the preparation of 2-amino-benzylamines Process for the preparation of 2-amino-benzylamines

C - Chemistry, Metallurgy

07

D

260/247.47, 260/

C07D 295/18 (2006.01) A61K 31/135 (2006.01) A61K 31/535 (2006.01) C07D 295/12 (2006.01) C07D 295/185 (2006.01)

Patent

CA 1052790

2-amino-benzylamine ABSTRACT OF THE DISCLOSURE The invention relates to a new process for the preparation of 2-amino-benzylamine derivatives having valuable pharmacological properties, in particular a secretolytic and/or antitussive activity. The process comprises the reaction of the corresponding 2-amino- benzyl alcohol with an appropriate amine, either the amino group being acylated or the reaction being performed in the presence of an organic acid. Examples of the proparation of certain 2-amino-benzylamine by means of the new process are given.

205312

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