C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.4
C07D 473/04 (2006.01) C07D 473/06 (2006.01) C07D 473/08 (2006.01) C07D 473/10 (2006.01)
Patent
CA 1062710
ABSTRACT OF THE DISCLOSURE A process for the preparation of compounds of general formula Image (I) (wherein one of the groups R1, R2 and R3 represent an (.omega.-1)-hydroxyalkyl group containing 4 to 8 carbon atoms being unbranched in the (.omega.-1)-position and the other of the groups R1, R2 and R3, which may be the same or differ- ent, each represents an alkyl group containing 1 to 12 carbon atoms or a hydrogen atom with the proviso that R2 does not represent a hydrogen atom) which is selected from the group consisting of A) hydrating a compound of formula Image (I') (wherein one of the groups R1', R2' and R3' represent an (.omega.-1)-alkenyl group containing 4 to 8 carbon atoms being unbranched in the (.omega.-1)-position and the other of the groups R1', R2' and R3' are as hereinbefore defined for the groups R1, R2 and R3 which do not represent an (.omega.-1)-hydroxyalkyl group) in the presence of a dilute acid or an ion exchange resin containing sulphonic acid groups and adding B) a hydrogen halide to a compound of formula (I') in conventlonal manner to produce an (.omega.-1)-halogenoalkyl com- pound and then saponifying said compound in conventional manner to yield the (.omega.-1)-hydroxyalkyl compound and compounds of formula (I'). These com- pounds find use in pharmacological preparations, for example to increase the rate of blood flow.
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