Process for the manufacture of steroid carboxylic acids and...

Details Process for the manufacture of steroid carboxylic acids and... Process for the manufacture of steroid carboxylic acids and...

C - Chemistry, Metallurgy

07

J

260/15, 260/28,

C07J 1/00 (2006.01) C07J 3/00 (2006.01) C07J 7/00 (2006.01) C07J 63/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1091223

Abstract of the Disclosure The present invention provides a novel process for the manufacture of 17- and 17a-carboxylic acids of the androstane and D-hemo-androstane series respectively,of the following partial formula of the ring D Image (I) wherein R represents a hydrogen atom or an unsubstituted or substituted hydrocarbon radical or a free or functionally ??dified hydroxyl group, and wherein the carboxyl group can be in the .alpha.- or .beta.-position, and of the salts and functional acid derivatives thereof, in particular their esters. The new process consists in the oxidative degradation of the side chain of corresponding 20, 21-ketoaldehydes of the pregnane or D-homopregnane series or of the 17.alpha.-pregnane or 17.alpha.a-D-homopregnane series with an organic peracid in an incrt solvent, preferably at temperatures betheen -20 and +30°C.

276066

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