Imidazole derivatives, their production and use

Details Imidazole derivatives, their production and use Imidazole derivatives, their production and use

C - Chemistry, Metallurgy

07

D

260/315.25

C07D 233/54 (2006.01) C07D 233/90 (2006.01)

Patent

CA 1152515

ABSTRACT OF THE DISCLOSURE The present invention relates to novel imidazole derivatives which are of value as medicines and to their production and use. More particularly, the present invention provides compounds of the formula (I): . (I) Image wherein R1 is lower alkyl, or phenyl-C1-2alkyl which may be substituted with halogen or nitro; R2 is lower alkyl, cycloalkyl or, phenyl which may be sub- stituted with halogen, lower alkyl, lower alkoxyl or di(lower alkyl)amino; one of R3 and R4 is of the formula: -(CH2)n-COR5 in the formula R5 is amino, lower alkoxyl or hydroxyl and n is integer of 0, 1 or 2, and the other is hydrogen or halogen; provided that R1 is lower alkyl or phenethyl when R3 is halogen, n is 1 and R5 is lower alkoxyl or hydroxyl, and its salts which have the excellent angiotension II antagonistic activity and hypotensive activity and are useful as a hypotensive agent.

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