Process for the manufacture of 5-mercapto- 1,2,3-triazoles

Details Process for the manufacture of 5-mercapto- 1,2,3-triazoles Process for the manufacture of 5-mercapto- 1,2,3-triazoles

C - Chemistry, Metallurgy

07

D

260/313

C07D 249/04 (2006.01) C07D 285/06 (2006.01)

Patent

CA 1137495

ABSTRACT Process for the manufacture of 5-mercapto- 1, 2, 3-triazoles 5-Mercapto-1,2,3-triazoles of the formula I Image (I) (in which R1 represents H or optionally substituted C1-C4- alkyl), suitable as starting materials for the production of antibiotics, preferably cephalosporin derivatives, are prepared by reacting a 1,2,3-thiadiazole-4-R1-5-carboxylic acid azide with an alcohol or phenol to form a (1,2,3- thiadiazol-4-R1-5-yl)-carbamic acid ester, hydrolysing the carbamic acid ester in the presence of an acid or base to form a 5-amino-4-R1-1,2,3-thiadiazole and rearranging the 5-amino-4-R1-1,2,3-thiadiazole in the presence of a base.

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