A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/187
A61K 31/42 (2006.01) A61K 31/43 (2006.01) A61K 31/545 (2006.01)
Patent
CA 1100406
ABSTRACT A pharmaceutical composition which comprises a compound of the form- ula II Image II wherein R1 and R2 can be an alkyl, alkenyl, phenylalkyl or phenylalkenyl group optionally inertly substituted by a halogen, OH, OR3, O.CO2R3, SR3, or a COR3 group wherein R3 is a hydrocarbon group of up to 8 carbon atoms and the group NR1R2 contains a total of not more than 16 carbon atoms and esters of compounds of formula II and acid addition salts thereof, said esters having the following formula IV and V Image IV Image V wherein R1 and R2 are as defined above and A is an alkyl group of 1 - 8 carbon atoms optionally substituted by halogen or a group of the formula OA4, OCOA4, SA4, SO2A wherein A4 is a hydrocarbon group of up to 6 carbon atoms; A2 is a hydrogen atom, an alkyl group of up to 4 carbon atoms or a phenyl group op- tionally substituted by halogen or by a group A5 or OA5 where A5 is an alkyl group of up to 6 carbon atoms; and A3 is a phenyl group optionally substituted by halogen or by a group A5 or OA5 where A5 is an alkyl group of up to 6 car- bon atoms or being selected from the group of esters consisting of phthalidyl, acetoxymethyl, pivaloyloxyethyl, ?-acetoxyethyl, ethoxycarbonyloxymethyl, and ?-ethoxycarbonyloxyethyl and a penicillin or a cephalosporin and a pharmaceutical carrier therefor.
353771
Howarth Thomas T.
Ponsford Roger J.
Stirling Irene
Beecham Group Limited
Borden Ladner Gervais Llp
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