Phenyl-alkanoic acid derivative and preparation thereof

Details Phenyl-alkanoic acid derivative and preparation thereof Phenyl-alkanoic acid derivative and preparation thereof

C - Chemistry, Metallurgy

07

D

260/514, 260/291

C07D 209/34 (2006.01) C07C 205/56 (2006.01) C07D 213/643 (2006.01) C07D 295/185 (2006.01)

Patent

CA 1127160

ABSTRACT OF THE DISCLOSURE New phenyl alkanoic acids are provided of the formula: Image wherein R1 is aralkyl containing up to 10 carbon atoms in the aryl moiety and 1 to 4 carbon atoms in the alkyl moiety or phenyl substituted with halogen, amino, lower alkyl, lower alkoxy or carboxy(lower)alkyl, R2 is hydrogen or halogen, R3 is amino, mono-alkylamino, di-alkylamino or mesylamino, R4 is a group of the formula CnH2n in which n is an integer of 1 or 2, and A is oxy, thio, sulfinyl, sulfonyl or imino, and the derivatives at the carboxy group, and pharmaceutically acceptable salts thereof; the new acids have anti-inflammatory, analgesic and antipyretic activities.

333296

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