Carboxy-phenyl or tolyl-dialkyl or alkylphenyl-sulphonium...

Details Carboxy-phenyl or tolyl-dialkyl or alkylphenyl-sulphonium... Carboxy-phenyl or tolyl-dialkyl or alkylphenyl-sulphonium...

A - Human Necessities

61

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260/474, 260/514

A61K 31/235 (2006.01) A61K 31/095 (2006.01) A61K 31/10 (2006.01) A61K 31/185 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01)

Patent

CA 1137107

Abstract of the Disclosure Novel compounds of formula Image z? in which R1 = (C8-24)alkyl, R2 = (C1-6)alkyl or unsubstituted or sub- stituted phenyl, R3 = H, halogen, (C1-3)alkyl or alkoxy, R4 = H, (C1-6)alkyl, n = 0 or 1, z? = anion forming a pharmaceutically accept- able non-toxic salt of the corresponding cation, provided that R2 is alkyl when R4 is H. The sulphonium compounds are obtained by alkyl- ation of corresponding alkylthio or phenylthio-phenyl compounds with alkyl halides in the presence of a metal salt or with a trialkyloxonium tetrafluoroborate after which the resulting anion can be replaced by known anion exchange methods. The compounds are active against obesity.

332672

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