Phenylalkanoic acid derivatives

Details Phenylalkanoic acid derivatives Phenylalkanoic acid derivatives

C - Chemistry, Metallurgy

07

D

167/244, 260/351

C07D 319/04 (2006.01) A61K 31/335 (2006.01) C07C 33/46 (2006.01) C07C 43/23 (2006.01) C07D 319/06 (2006.01) C07D 319/08 (2006.01) C07D 407/02 (2006.01)

Patent

CA 1258862

A B S T R A C T PHEUYLALKANOIC ACID DERIVATIVES The invention concerns novel [(4-phenyl-1,3-dioxan-cis-5-yl)alkyl]phenylalkanoic acids of the formula I wherein Ra and Rb are a variety of substituents including alkyl, alkenyl, halogenoalkyl, phenyl and benzyl, or together form polymethylene; Rc is hydroxy, alkoxy or alkanesulphonamido; A1 and A2 are polymethylene; X is oxygen, sulphur or a direct bond; and benzene ring A bears a variety of substituents; and, when Rc is hydroxy, the physiologically acceptable salts thereof. The compounds of formula I are thromboxane antagonists of value in treating a variety of disease conditions. The invention also provides processes for the manufacture of, and pharmaceutical compositions of, the compounds of formula I.

466827

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