Process for the preparation of 2-carboxypyrazine 4- oxides

Details Process for the preparation of 2-carboxypyrazine 4- oxides Process for the preparation of 2-carboxypyrazine 4- oxides

C - Chemistry, Metallurgy

07

D

260/268

C07D 237/24 (2006.01) C07D 241/24 (2006.01)

Patent

CA 1276933

ABSTRACT OF THE DISCLOSURE A process for the preparation of 2-carboxypyrazine 4-oxides having the formula (I) Image (I) wherein R1, R2 and R3, which may be the same or different, represent a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms, by oxidation of the corresponding 2- carboxypyrazines. The 2-carboxypyrazines are reacted under stirring with an aqueous solution of H2O2, at a pH ranging between 0.5 and 5, in the presence of a catalyst selected from the group consisting of tungstic acid, a homopolytungstic acid, a heteropolytungstic acid, molybdic acid, a homopolymolybidic acid, a heteropolymolybdic acid, and an alkali metal salt thereof. 2- carboxypyrazine 4-oxides are pharmaceutical products having hypoglycaemic and hypolipaemic activity.

508998

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