N-¬(amino)alkyl|-1-pyrrolidine, 1-piperidine and...

Details N-¬(amino)alkyl|-1-pyrrolidine, 1-piperidine and... N-¬(amino)alkyl|-1-pyrrolidine, 1-piperidine and...

C - Chemistry, Metallurgy

07

D

167/208, 260/291

C07D 207/08 (2006.01) C07D 207/12 (2006.01) C07D 207/34 (2006.01) C07D 211/20 (2006.01) C07D 211/54 (2006.01) C07D 223/04 (2006.01) C07D 223/06 (2006.01)

Patent

CA 1247093

N-[(AMINO)ALKYL]-1-PYRROLIDINE, 1-PIPERIDINE AND 1-HOMOPIPERIDINECARBOXAMIDES (AND THIOCARBOXAMIDES) WITH SULFUR LINKED SUBSTITUTION IN THE 2, 3 OR 4-POSITION ABSTRACT OF THE DISCLOSURE Novel pyrrolidine, piperidine and homopiperidine- carboxamide and thiocarboxamide compounds having the formula: Image wherein X is -S-, -S(O)- or -S(O)2-; A is a loweralkylene chain and A1 and A2 are alkylene chains when p and d are one; R, R1 and R2 are hydrogen, loweralkyl, phenyl,cyclo- alkyl or phenylalkyl and R1 and R2 may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts useful as cardiac antiarrhythmia agents are disclosed. Novel chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with -(A2)p-X-(A2)d-Q side chain are also disclosed.

478539

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