C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.01
C07D 487/14 (2006.01)
Patent
CA 1225645
A b s t r a c t SUBSTITUTED 9H-8-OXO-PYRIMIDO[2,1-f]PURINE-2,4-DIONES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. The new compounds are compounds of formula (I) (I) Image and its tautomer and the pharmaceutically acceptable salts thereof, wherein R1 and R2 are the same or different and are hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl; alkyl substituted by cycloalkyl, aryl or heterocyclic radical; - 2 - R3 is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, acyloxyalkyl, oxoalkyl, aryl; alkyl sub- stituted by cycloalkyl, cycloalkenyl, aryl, hydroxy, cyano, halo or heterocyclic radical; -alkyl-X-CnH2n+1 wherein X is O,S,S+-O-, SO2 or -N-CpH2p+1; -(CH2)qC(O)NR6R7 or -(CH2)rC(O)OR8; R4 is hydrogen, alkyl, aryl, a heterocyclic radical; or alkyl substituted by cycloalkyl aryl or a hetero- cyclic radical; R5 is hydrogen acyl, or alkyl. These compounds are useful as antiinflammatory agents for treating inflammatory conditions such as arthritis, spondylitis, and tendonitis in mammals.
439400
Ogilvy Renault
Schering Corporation
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