Cyclic prodrugs of antiinflammatory oxicams

Details Cyclic prodrugs of antiinflammatory oxicams Cyclic prodrugs of antiinflammatory oxicams

C - Chemistry, Metallurgy

07

D

167/215, 260/243

C07D 513/04 (2006.01) C07D 513/14 (2006.01)

Patent

CA 1234813

PC(Ph) 6833 CYCLIC PRODRUGS OF ANTIINFLAMMATORY OXICAMS ABSTRACT Compounds of the formula Image (I) (II) or a pharmaceutically acceptable acid addition salt thereof wherein R is 2-pyridyl, 6-chloro-2-pyridyl, 6- methyl-2-pyridyl or 5-methylisoxazol-3-yl; useful as prodrug forms of the corresponding known oxicam antiinflam- matory and analgesic agents, piroxicam, the corresponding 6-chloro-2-pyridyl and 6-methyl-2-pyridylcarboxamides, isoxicam and tenoxicam; methods for their use, pharmaceutical compositions containing them and a process for their preparation.

484473

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