Quinolone compounds

Details Quinolone compounds Quinolone compounds

C - Chemistry, Metallurgy

07

D

260/277.1, 260/2

C07D 401/04 (2006.01) C07D 215/58 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 1198425

- 43 - NEW QUINOLONE COMPOUNDS ABSTRACT Novel 1-R-1,4-dihydro-4-oxo-6-fluoro-7-(Z=N-)- quinolinecarboxylic acids and esters thereof, where R is amino, lower-alkylamino, 2-propenylamino or di-lower-alkyl- amino, R" is hydrogen or lower-alkyl, and Z=N is a hetero- cyclic group, useful as antibacterial agents, are prepared by reacting the corresponding 7-chloroquinoline derivatives with the appropriate heterocyclic compound, Z=NH. A preferred group of compounds are those where Z=N is 1-piperazinyl or 4-lower-alkyl-1-piperazinyl.

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