Process for the production of protein products in...

Details Process for the production of protein products in... Process for the production of protein products in...

C - Chemistry, Metallurgy

12

N

C12N 15/80 (2006.01) C12N 1/15 (2006.01) C12N 15/11 (2006.01) C12N 15/56 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1341593

A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding functions facilitating gene expression, a suitable marker for selection of transformants, and a DNA-sequence encoding the desired protein product. The process enables industrial production of many different polypeptides and proteins in A. oryzae. Examples of such products are chymosin or prochymosin and other rennets, proteases, lipases and amylases. Also disclosed is an effective promoter for expression of a protein in Aspergillus. A preferred promoter is the TAKA-amylase promoter or functional parts thereof.

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