Synthesis of optically active aryloxypropanolamines and...

Details Synthesis of optically active aryloxypropanolamines and... Synthesis of optically active aryloxypropanolamines and...

C - Chemistry, Metallurgy

07

C

260/602, 260/479

C07C 217/64 (2006.01) C07C 219/06 (2006.01) C07D 209/08 (2006.01) C07D 209/30 (2006.01) C07D 209/52 (2006.01) C07D 209/88 (2006.01) C07D 215/227 (2006.01) C07D 235/26 (2006.01) C07D 237/20 (2006.01) C07D 239/545 (2006.01) C07D 261/08 (2006.01) C07D 285/10 (2006.01) C07D 295/195 (2006.01) C07D 307/12 (2006.01) C07D 307/46 (2006.01) C07D 307/80 (2006.01) C07D 307/88 (2006.01) C07D 311/20 (2006.01) C07D 335/06 (2006.01) C07D 473/08 (2006.01) C07D 493/04 (2006.01)

Patent

CA 1313669

ABSTRACT OF THE DISCLOSURE Described is a process for preparing a racemic or chiral aryloxypro- panolamine (1) or arylethanolamine (2) of the formula Image or Image 1 2 wherein Ar is aryl, substituted aryl, heteroaryl, or aralkyl and R is alkyl, substituted alkyl, aralkyl, or WB wherein W is a straight or branched chain alkylene of from 1 to about 6 carbon atoms and wherein B is -NR2COR3, -NR2CONR3R4, -NR2SO2R3, -NR2SO2NR3R4, or -NR2COOR5, where R2, R3, R4, and R5 may be the same or different and may be hydrogen, alkyl, alkoxy- alkyl, alkoxyaryl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R3 and R5 are not hydrogen when B is -NR2SO2R3 or -NR2COOR5, or R3 and R4 may together with N form a 5- to 7-membered heterocyclic group. The process can be used to prepare beta-blocking agents, useful in the treatment of cardiac conditions.

522977

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