Proteinaceous antigens with conformation-independent and...

Details Proteinaceous antigens with conformation-independent and... Proteinaceous antigens with conformation-independent and...

C - Chemistry, Metallurgy

07

K

167/129, 167/44

C07K 17/00 (2006.01) C07K 14/02 (2006.01) G01N 33/531 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1272126

ABSTRACT A single polypeptide antigen that includes the amino acid residue sequence and epitope of a conformation-independent antigenic determinant and the amino acid residue sequence but lacks the epitope of a conformation-dependent antigenic determinant is disclosed as are methods of its manufacture and use and articles of manufacture using the same. The uses of the pre-S(2) region polypeptide encoded by the hepatitis B virus genome as a T cell proliferating agent and as a potentiator for enhancing the humoral immune response of animals that exhibit a low humoral response to an S region-containing immunogen are also disclosed.

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