Substituted 4,5-dihydro-6-(substituted) phenyl-3(2h)-...

Details Substituted 4,5-dihydro-6-(substituted) phenyl-3(2h)-... Substituted 4,5-dihydro-6-(substituted) phenyl-3(2h)-...

C - Chemistry, Metallurgy

07

D

260/264.7

C07D 237/02 (2006.01) C07D 403/10 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1190548

ABSTRACT Substituted 4,5-dihydro-6-(substituted)- phenyl-3(2H)-pyridazinone compounds and 6-(sub- stituted)phenyl-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents. Said compounds cause a significant increase in myocardial contractility in the dog. Said compounds also cause a decrease in blood pressure in the spontaneously hypertensive rat. Said compounds are produced by reacting substituted .gamma.-oxobenzene- butanoic acids with suitably substituted hydrazines to provide 4,5-dihydro-6-(substituted)phenyl-3(2H)- pyridazinones which are dehydrogenated to 6-(sub- stituted)phenyl-3(2H)-pyridazinones. Both the intermediate 4,5-dihydro-6-(substituted)- phenyl-3(2H)-pyridazinones and the 6-(substituted)- phenyl-3(2H)-pyridazinones are useful as cardiotonic and antihypertensive agents.

411513

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