Heterocyclic-substituted quinolone inotropic agents

Details Heterocyclic-substituted quinolone inotropic agents Heterocyclic-substituted quinolone inotropic agents

C - Chemistry, Metallurgy

07

D

167/211, 260/251

C07D 401/00 (2006.01) C07D 213/40 (2006.01) C07D 215/18 (2006.01) C07D 215/227 (2006.01) C07D 215/28 (2006.01) C07D 215/48 (2006.01) C07D 215/54 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 1253497

9387-64 Abstract of the Disclosure A quinolone inotropic agent of the formula:- Image --- (I) or a pharmaceutically acceptable salt thereof, wherein "Het" is an optionally substituted 5- or 6-membered monocyclic aromatic heterocyclic group attached by a carbon atom to the 5-, 6-, 7- or 8- position of said quinolone; R, which is attached to the 5-, 6-, 7- or 8- position, is hydrogen, C1-C4 alkyl; C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulphinyl, C1-C4 alkylsulphonyl, halo, CF3, hydroxy, hydroxymethyl, or cyano; R1 is hydrogen, cyano, (C1-C4 alkoxy)- carbonyl, C1-C4 alkyl, nitro, halo, -NR3R4 or -CONR3R4 where R3 and R4 are each independently H or C1-C4 alkyl or together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocyclic group optionally containing a further heteroatom or group selected from O, S and N-R5 where R5 is H or C1-C4 alkyl; R2 is H, C1-C4 alkyl, or 2-hydroxyethyl; Y is H or C1-C4 alkyl; and the dotted line between the 3- and 4- positions represents an optional bond, these novel compounds and their pharmaceutically acceptable salts being cardiac stimulants useful in the curative or prophylactic treatment of cardiac conditions, in particular heart failure. PLC 391/A (SPC 6780/A)

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